Impact of dry ejaculation caused by highly selective alpha1A-blocker: randomized, double-blind, placebo-controlled crossover pilot study in healthy volunteer men.

@article{Shimizu2010ImpactOD,
  title={Impact of dry ejaculation caused by highly selective alpha1A-blocker: randomized, double-blind, placebo-controlled crossover pilot study in healthy volunteer men.},
  author={Fumitaka Shimizu and Masataka Taguri and Yoshiko Harada and Yutaka Matsuyama and Kazuhiro Sase and Makoto Fujime},
  journal={The journal of sexual medicine},
  year={2010},
  volume={7 3},
  pages={1277-83}
}
INTRODUCTION Dry ejaculation with loss of seminal emission is reported in patients who have been administered silodosin, an alpha1A-adrenoceptor antagonist. AIM We investigated the impact of dry ejaculation caused by orally administered silodosin on orgasmic function. METHODS In a double-blind crossover study, 50 healthy volunteer men were randomly assigned to receive either a single dose of 4-mg silodosin or placebo with 3 days of washout before crossover. Subjects masturbated 4 hours… CONTINUE READING