Impact of donor and recipient IL28B rs12979860 genotypes on hepatitis C virus liver graft reinfection.

  title={Impact of donor and recipient IL28B rs12979860 genotypes on hepatitis C virus liver graft reinfection.},
  author={Christian Lange and Darius Moradpour and Alexandra Doehring and Hans-Anton Lehr and Beat Muellhaupt and St{\'e}phanie Bibert and Pierre-Yves Bochud and Anca Teodora Antonino and M Virginia Pascual and Harald Farnik and Ying Shi and Wolf O Bechstein and Christian M{\"o}nch and Martin-Leo Hansmann and Christoph Sarrazin and J{\"o}rn L{\"o}tsch and Stefan Zeuzem and W. Hofmann},
  journal={Journal of hepatology},
  volume={55 2},
BACKGROUND & AIMS Recent studies have described a major impact of genetic variations near the IL28B gene on the natural course and outcome of antiviral therapy in chronic hepatitis C. We therefore, aimed to explore the impact of donor and recipient genotypes of these polymorphisms on hepatitis C virus (HCV) liver graft reinfection. METHODS Donor and recipient genotypes of IL28B rs12979860C>T single nucleotide polymorphism were determined in 91 patients with HCV liver graft reinfection, 47 of… CONTINUE READING
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  • N Akuta, F Suzuki, M Hirakawa, Y Kawamura, H Yatsuji, H Sezaki
  • Hepatology
  • 2010
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Hepatic ISG expression is associated with genetic variation in IL28B and the outcome of IFN therapy for chronic hepatitis C. Gastroenterology 2010;139:499–502

  • M Honda, A Sakai, T Yamashita, Y Nakamoto, E Mizukoshi, Y Sakai
  • 2010
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IL28B gene polymorphism influences histological and biochemical severity of graft hepatitis after liver transplantation for HCV-induced liver disease

  • D Eurich, S Boas-Knoop, M Ruehl, M Schulz, ED Carrillo, M Bahra
  • J Hepatol 2010;52:450
  • 2010
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  • AJ Thompson, AJ Muir, MS Sulkowski, D Ge, J Fellay, KV Shianna
  • Gastroenterology
  • 2010
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