Impact of disrupting adenosine A₃ receptors (A₃⁻/⁻ AR) on colonic motility or progression of colitis in the mouse.

@article{Ren2011ImpactOD,
  title={Impact of disrupting adenosine A₃ receptors (A₃⁻/⁻ AR) on colonic motility or progression of colitis in the mouse.},
  author={Tianhua Ren and Iveta S Grants and Mazin A. Alhaj and Matt McKiernan and Marlene Jacobson and Hamdy H. Hassanain and W Gordon Frankel and Jacqueline E Wunderlich and Fievos L Christofi},
  journal={Inflammatory bowel diseases},
  year={2011},
  volume={17 8},
  pages={
          1698-713
        }
}
BACKGROUND Pharmacological studies suggest that adenosine A₃AR influences motility and colitis. Functional A₃⁻/⁻AR knockout mice were used to prove whether A₃AR activation is involved in modulating either motility or colitis. METHODS A₃AR was probed by polymerase chain reaction (PCR) genotyping, Western blot, and immunochemistry. Motility was assessed in vivo by artificial bead-expulsion, stool-frequency, and FITC-dextran transit. Colitis was induced with dextran sodium sulfate (DSS) in A… CONTINUE READING
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