Impact of diisobutyl phthalate and other PPAR agonists on steroidogenesis and plasma insulin and leptin levels in fetal rats.

@article{Boberg2008ImpactOD,
  title={Impact of diisobutyl phthalate and other PPAR agonists on steroidogenesis and plasma insulin and leptin levels in fetal rats.},
  author={Julie Boberg and Stine Broeng Metzdorff and Rasmus Wortziger and Marta Axelstad and Leon J. S. Brokken and Anne Marie Vinggaard and Majken Dalgaard and Christine Nellemann},
  journal={Toxicology},
  year={2008},
  volume={250 2-3},
  pages={75-81}
}
Endocrine disrupting chemicals can induce malformations and impairment of reproductive function in experimental animals and may have similar effects in humans. Recently, the environmental obesogen hypothesis was proposed, suggesting that environmental chemicals contribute to the development of obesity and insulin resistance. These effects could be related to chemical interaction with nuclear receptors such as the peroxisome proliferator activated receptors (PPARs). As several testosterone… CONTINUE READING
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