Impact of different saturated fatty acid, polyunsaturated fatty acid and cholesterol containing diets on beta-amyloid accumulation in APP/PS1 transgenic mice.

@article{Oksman2006ImpactOD,
  title={Impact of different saturated fatty acid, polyunsaturated fatty acid and cholesterol containing diets on beta-amyloid accumulation in APP/PS1 transgenic mice.},
  author={Mari Oksman and Henna Iivonen and Endre Hogyes and Zareen Amtul and Botond Penke and Inge Leenders and Laus M Broersen and Dieter L{\"u}tjohann and Tobias Hartmann and Heikki Tanila},
  journal={Neurobiology of disease},
  year={2006},
  volume={23 3},
  pages={563-72}
}
The present study assessed the influence of dietary lipids on accumulation of amyloid beta-peptide (Abeta) in the brain. Seven experimental diets with varying n-6/n-3-ratio, saturated and polyunsaturated fatty acid and cholesterol contents were fed to transgenic APPswe/PS1dE9 mice for 3-4 months beginning at a young adult age (6 months). Hippocampal Abeta levels were determined with ELISA and plaque load by using immunocytochemistry. A typical Western diet with 40% saturated fatty acids and 1… CONTINUE READING
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