Impact of deep freezing on the stability of 25 mg/ml vancomycin ophthalmic solutions.

@article{SautouMiranda2002ImpactOD,
  title={Impact of deep freezing on the stability of 25 mg/ml vancomycin ophthalmic solutions.},
  author={Val{\'e}rie Sautou-Miranda and Fr{\'e}d{\'e}ric Libert and Anne Grand-Boyer and Christophe Gellis and Jean Chopineau},
  journal={International journal of pharmaceutics},
  year={2002},
  volume={234 1-2},
  pages={205-12}
}
For the treatment of certain eye infections, ophthalmic solutions 'laced' with 25 mg/ml vancomycin are sometimes prepared. Their physical and chemical stability and the maintenance of their sterility were studied after deep freezing at -20 +/- 2 degrees C and thawing, followed or not by refrigeration for 48 h at 4 +/- 2 degrees C. Physical and chemical… CONTINUE READING