Impact of cytosine methylation on DNA binding specificities of human transcription factors

  title={Impact of cytosine methylation on DNA binding specificities of human transcription factors},
  author={Yimeng Yin and E. Morgunova and A. Jolma and Eevi Kaasinen and B. Sahu and Syed Khund-Sayeed and P. Das and T. Kivioja and Kashyap Dave and F. Zhong and K. R. Nitta and M. Taipale and A. Popov and P. Ginno and S. Domcke and Jian Yan and D. Sch{\"u}beler and C. Vinson and J. Taipale},
  • Yimeng Yin, E. Morgunova, +16 authors J. Taipale
  • Published 2017
  • Biology, Medicine
  • Science
  • Positives and negatives of methylated CpG When the DNA bases cytosine and guanine are next to each other, a methyl group is generally added to the pyrimidine, generating a mCpG dinucleotide. This modification alters DNA structure but can also affect function by inhibiting transcription factor (TF) binding. Yin et al. systematically analyzed the effect of CpG methylation on the binding of 542 human TFs (see the Perspective by Hughes and Lambert). In addition to inhibiting binding of some TFs… CONTINUE READING
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