Impact of cyclophosphamide on long-term reduction in sperm count in men treated with combination chemotherapy for Ewing and soft tissue sarcomas.

@article{Meistrich1992ImpactOC,
  title={Impact of cyclophosphamide on long-term reduction in sperm count in men treated with combination chemotherapy for Ewing and soft tissue sarcomas.},
  author={Marvin L. Meistrich and Gregory Wilson and Barry W. Brown and M F da Cunha and Larry I. Lipshultz},
  journal={Cancer},
  year={1992},
  volume={70 11},
  pages={2703-12}
}
BACKGROUND Treatment of cancer with multiple-drug chemotherapy regimens or radiation therapy can cause either temporary azoospermia of various durations or permanent azoospermia in young men. METHODS To identify which drugs in which doses contribute to long-term or permanent azoospermia, semen analyses were done on patients with Ewing and soft tissue sarcomas before, during, and after treatment with either CYADIC (cyclophosphamide, doxorubicin, and dacarbazine), or CYVADIC (vincristine added… CONTINUE READING