Impact of copolymer ratio on drug distribution in styrene-isobutylene-styrene block copolymers.

@article{Mcdermott2013ImpactOC,
  title={Impact of copolymer ratio on drug distribution in styrene-isobutylene-styrene block copolymers.},
  author={Martin K. Mcdermott and Chang-soo Kim and David M Saylor and Dinesh V. Patwardhan},
  journal={Journal of biomedical materials research. Part B, Applied biomaterials},
  year={2013},
  volume={101 7},
  pages={
          1191-9
        }
}
Drug-polymer composite coatings, composed of styrene-isobutylene-styrene (SIBS) tri-block copolymers, are frequently used in controlled drug release biomedical device applications. In this work, we used atomic force microscopy to characterize the effects of different drug loadings and polymer chemistries (i.e., block copolymer ratio) on the variation of surface structures and compositions of SIBS-tetracycline (SIBS-TC) cast composites including tetracycline (TC) drug amount, drug phase size… Expand
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