Impact of chronic beta-adrenoceptor activation on neurotensin-induced myocardial effects in rats.

@article{Osadchii2006ImpactOC,
  title={Impact of chronic beta-adrenoceptor activation on neurotensin-induced myocardial effects in rats.},
  author={Oleg E Osadchii and Gavin Robert Norton and Dawn A J Deftereos and Dee Muller and Angela Jill Woodiwiss},
  journal={European journal of pharmacology},
  year={2006},
  volume={553 1-3},
  pages={246-53}
}
In heart failure chronic sympathetic activation results in contractile dysfunction in part through down-regulation of the beta-adrenoceptor-cAMP system. However, the impact of chronic adrenergic activation on cardiac sympathetic neuromodulator systems is unclear. In this study, we sought to determine whether chronic adrenergic activation modifies myocardial norepinephrine release and contractile responses elicited by neurotensin, a neuropeptide found in cardiovascular system. Chronic… CONTINUE READING
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