Impact of cerebrospinal fluid matrix on the detection of Alzheimer's disease with Aβ42 and influence of disease on the total-Aβ42/Aβ40 ratio.

@article{Slemmon2015ImpactOC,
  title={Impact of cerebrospinal fluid matrix on the detection of Alzheimer's disease with Aβ42 and influence of disease on the total-Aβ42/Aβ40 ratio.},
  author={J. Randall Slemmon and Alice Shapiro and Marc H Mercken and Johannes Rolf Streffer and Gary Romano and Niels Andreasen and Henrik Zetterberg and K Blennow},
  journal={Journal of neurochemistry},
  year={2015},
  volume={135 5},
  pages={1049-58}
}
The 42-amino acid fragment of amyloid β (Aβ1-42) in cerebrospinal fluid has continued to be important for detecting cerebral β-amyloidosis in Alzheimer's disease (AD). However, there are impediments to our ability to fully understand this measurement, including matrix interference and changes linked to apolipoprotein E (APOE) ε4 genotype. This study investigated matrix interference as a contributing factor for detecting AD in APOE ε4-negative patients by comparing total extractable Aβ1-42 to… CONTINUE READING

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