Impact of bronchial epithelium on dendritic cell migration and function: modulation by the bacterial motif KpOmpA.

@article{Pichavant2006ImpactOB,
  title={Impact of bronchial epithelium on dendritic cell migration and function: modulation by the bacterial motif KpOmpA.},
  author={Muriel Pichavant and Solenne Taront and Pascale Jeannin and La{\"e}titia Breuilh and A S Charbonnier and Corentin Spriet and Catherine Fourneau and Nathalie Corvaia and Laurent H{\'e}liot and Anne Brichet and A. B. Tonnel and Yves Delneste and Philippe Gosset},
  journal={Journal of immunology},
  year={2006},
  volume={177 9},
  pages={5912-9}
}
Mucosal immune response depends on the surveillance network established by dendritic cells (DC), APC localized within the epithelium. Bronchial epithelial cells (BEC) play a pivotal role both in the host defense and in the pathogenesis of inflammatory airway disorders. We previously showed that the outer membrane protein A from Klebsiella pneumoniae (KpOmpA), a pathogen-associated molecular pattern (PAMP) derived from Klebsiella pneumoniae, activates BEC. In this study, we evaluated the… CONTINUE READING

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