Impact of brain-behavior phenotypying of genetically-engineered mice on research of neuropsychiatric disorders

@article{Takao2007ImpactOB,
  title={Impact of brain-behavior phenotypying of genetically-engineered mice on research of neuropsychiatric disorders},
  author={Keizo Takao and Nobuyuki Yamasaki and Tsuyoshi Miyakawa},
  journal={Neuroscience Research},
  year={2007},
  volume={58},
  pages={124-132}
}
Despite massive research efforts, the exact pathogenesis and pathophysiology of psychiatric disorders, such as schizophrenia and bipolar disorder, remain largely unknown. Animal models can serve as essential tools for investigating the etiology and treatment of such disorders. Since the introduction of gene targeting techniques, the functions of more than 10% of all known mouse genes have been investigated by creating mutant mice. Some of these mutant mouse strains were found to exhibit… CONTINUE READING

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