Impact of blindness onset on the functional organization and the connectivity of the occipital cortex.

@article{Collignon2013ImpactOB,
  title={Impact of blindness onset on the functional organization and the connectivity of the occipital cortex.},
  author={Olivier Collignon and Giulia Dormal and Genevi{\`e}ve Albouy and Gilles Vandewalle and Patrice Voss and Christophe Phillips and Franco Lepore},
  journal={Brain : a journal of neurology},
  year={2013},
  volume={136 Pt 9},
  pages={2769-83}
}
Contrasting the impact of congenital versus late-onset acquired blindness provides a unique model to probe how experience at different developmental periods shapes the functional organization of the occipital cortex. We used functional magnetic resonance imaging to characterize brain activations of congenitally blind, late-onset blind and two groups of sighted control individuals while they processed either the pitch or the spatial attributes of sounds. Whereas both blind groups recruited… CONTINUE READING

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We then used a combination of dynamic causal modelling with Bayesian model selection to demonstrate that auditory - driven activity in primary visual cortex is better explained by direct connections with primary auditory cortex in the congenitally blind whereas it relies more on feedback inputs from parietal regions in the late - onset blind group .
Impact of blindness onset on the functional organization and the connectivity of the occipital cortex . Contrasting the impact of congenital versus late - onset acquired blindness provides a unique model to probe how experience at different developmental periods shapes the functional organization of the occipital cortex .
We then used a combination of dynamic causal modelling with Bayesian model selection to demonstrate that auditory - driven activity in primary visual cortex is better explained by direct connections with primary auditory cortex in the congenitally blind whereas it relies more on feedback inputs from parietal regions in the late - onset blind group .
Impact of blindness onset on the functional organization and the connectivity of the occipital cortex . Contrasting the impact of congenital versus late - onset acquired blindness provides a unique model to probe how experience at different developmental periods shapes the functional organization of the occipital cortex .
Occipital lobeIs location of anatomic structureArea striata structure
Taken together , these results demonstrate the crucial role of the developmental period of visual deprivation in ( re)shaping the functional architecture and the connectivity of the occipital cortex .
Whereas both blind groups recruited occipital regions for sound processing , activity in bilateral cuneus was only apparent in the congenitally blind , highlighting the existence of region - specific critical periods for crossmodal plasticity .
We then used a combination of dynamic causal modelling with Bayesian model selection to demonstrate that auditory - driven activity in primary visual cortex is better explained by direct connections with primary auditory cortex in the congenitally blind whereas it relies more on feedback inputs from parietal regions in the late - onset blind group .
Whereas both blind groups recruited occipital regions for sound processing , activity in bilateral cuneus was only apparent in the congenitally blind , highlighting the existence of region - specific critical periods for crossmodal plasticity .
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