Impact of biofilm on the in vitro activity of vancomycin alone and in combination with tigecycline and rifampicin against Staphylococcus aureus.

@article{Rose2009ImpactOB,
  title={Impact of biofilm on the in vitro activity of vancomycin alone and in combination with tigecycline and rifampicin against Staphylococcus aureus.},
  author={Warren E. Rose and Peter T Poppens},
  journal={The Journal of antimicrobial chemotherapy},
  year={2009},
  volume={63 3},
  pages={485-8}
}
OBJECTIVES This study evaluated vancomycin susceptibility and activity alone and in combination with rifampicin and tigecycline against low-biofilm- and high-biofilm-producing methicillin-resistant Staphylococcus aureus (MRSA) clinical isolates. METHODS Forty MRSA isolates recovered from bloodstream infections were analysed. Susceptibilities were performed in planktonic and biofilm cultures by microbroth dilution. Biofilm production was determined using an adherent plate assay. Time-kill… CONTINUE READING
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