Impact of arrhythmogenic calmodulin variants on small conductance Ca2+‐activated K+ (SK3) channels

@article{Saljic2019ImpactOA,
  title={Impact of arrhythmogenic calmodulin variants on small conductance Ca2+‐activated K+ (SK3) channels},
  author={Arnela Saljic and Kalai Mangai Muthukumarasamy and Jonas M. la Cour and Kim Boddum and Morten Grunnet and Martin W Berchtold and Thomas Jespersen},
  journal={Physiological Reports},
  year={2019},
  volume={7}
}
Calmodulin (CaM) is a ubiquitous Ca2+‐sensing protein regulating many important cellular processes. Several CaM‐associated variants have been identified in a small group of patients with cardiac arrhythmias. The mechanism remains largely unknown, even though a number of ion channels, including the ryanodine receptors and the L‐type calcium channels have been shown to be functionally affected by the presence of mutant CaM. CaM is constitutively bound to the SK channel, which underlies the… Expand
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Different arrhythmia-associated calmodulin mutations have distinct effects on cardiac SK channel regulation
Cardiac small-conductance Ca2+-activated K+ (SK) channels are gated solely by beat-to-beat changes in intracellular Ca2+. Ledford et al. show distinct mechanisms by which human calmodulin mutantsExpand

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