Impact of apoptotic adipose-derived mesenchymal stem cells on attenuating organ damage and reducing mortality in Rat sepsis syndrome induced by cecal puncture and ligation

@inproceedings{Chang2012ImpactOA,
  title={Impact of apoptotic adipose-derived mesenchymal stem cells on attenuating organ damage and reducing mortality in Rat sepsis syndrome induced by cecal puncture and ligation},
  author={Chien-Hung Chang and Steve Leu and Hsin-Ching Sung and Yen-yi Zhen and Chung-Lung Cho and Angela Shin-Yih Chen and Tzu-hsien Tsai and Sheng-ying Chung and Han-Tan Chai and Cheuk-Kwan Sun and Chia-Hung Yen and Hon-Kan Yip},
  booktitle={Journal of Translational Medicine},
  year={2012}
}
BackgroundWe tested whether apoptotic adipose-derived mesenchymal stem cells (A-ADMSCs) were superior to healthy (H)-ADMSCs at attenuating organ damage and mortality in sepsis syndrome following cecal ligation and puncture (CLP).MethodsAdult male rats were categorized into group 1 (sham control), group 2 (CLP), group 3 [CLP + H-ADMSC administered 0.5, 6, and 18 h after CLP], group 4 [CLP + A-ADMSC administered as per group 3].ResultsCirculating peak TNF-α level, at 6 h, was highest in groups 2… CONTINUE READING
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