Impact of antibiotic treatment and host innate immune pressure on enterococcal adaptation in the human bloodstream

@article{Tyne2019ImpactOA,
  title={Impact of antibiotic treatment and host innate immune pressure on enterococcal adaptation in the human bloodstream},
  author={Daria Van Tyne and Abigail L Manson and Mark M Huycke and John Karanicolas and Ashlee M Earl and Michael S. Gilmore},
  journal={Science Translational Medicine},
  year={2019},
  volume={11}
}
Multidrug-resistant enterococcal strains emerged in the early 1980s and are now among the leading causes of drug-resistant bacterial infection worldwide. We used functional genomics to study an early bacterial outbreak in patients in a Wisconsin hospital between 1984 and 1988 that was caused by multidrug-resistant Enterococcus faecalis. The goal was to determine how a clonal lineage of E. faecalis became adapted to growth and survival in the human bloodstream. Genome sequence analysis revealed… CONTINUE READING

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