Impact of amoxicillin therapy on resistance selection in patients with community-acquired lower respiratory tract infections: a randomized, placebo-controlled study.

@article{MalhotraKumar2016ImpactOA,
  title={Impact of amoxicillin therapy on resistance selection in patients with community-acquired lower respiratory tract infections: a randomized, placebo-controlled study.},
  author={Surbhi Malhotra-Kumar and Liesbet Van Heirstraeten and S. A. M. Coenen and Christine Lammens and Niels Adriaenssens and Anna Kowalczyk and Maciek Godycki-{\'C}wirko and Zuzana Bielicka and Helena Hupkov{\'a} and Christina Lannering and Sigvard M{\"o}lstad and Patricia Fernandez-Vandellos and Antoni Torres and Maxim Parizel and Margareta M. Ieven and Christopher C Butler and Theo J. M. Verheij and Paul Little and Herman Goossens},
  journal={The Journal of antimicrobial chemotherapy},
  year={2016},
  volume={71 11},
  pages={3258-3267}
}
OBJECTIVES To determine the effect of amoxicillin treatment on resistance selection in patients with community-acquired lower respiratory tract infections in a randomized, placebo-controlled trial. METHODS Patients were prescribed amoxicillin 1 g, three times daily (n = 52) or placebo (n = 50) for 7 days. Oropharyngeal swabs obtained before, within 48 h post-treatment and at 28-35 days were assessed for proportions of amoxicillin-resistant (ARS; amoxicillin MIC ≥2 mg/L) and -non-susceptible… CONTINUE READING
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