Impact of amino acid substitutions in hepatitis C virus genotype 1b core region on liver steatosis and glucose tolerance in non-cirrhotic patients without overt diabetes.

@article{Sumida2011ImpactOA,
  title={Impact of amino acid substitutions in hepatitis C virus genotype 1b core region on liver steatosis and glucose tolerance in non-cirrhotic patients without overt diabetes.},
  author={Yoshio Sumida and Kazuyuki Kanemasa and Tasuku Hara and Yutaka Inada and Kyoko Sakai and Shunsuke Imai and Naohisa Yoshida and Kohichiroh Yasui and Yoshito Itoh and Takeshi Okanoue and Toshikazu Yoshikawa},
  journal={Journal of gastroenterology and hepatology},
  year={2011},
  volume={26 5},
  pages={836-42}
}
BACKGROUND AND AIM The hepatitis C virus (HCV) core protein induces hepatic steatosis and glucose intolerance in transgenic mice. The aim of this study was to clarify the impact of mutations in the HCV core region on hepatic steatosis and glucose tolerance in patients with chronic hepatitis C. METHODS Seventy-four Japanese patients (27 men, 47 women; mean age, 61.9 years) infected with HCV 1b with high viral load (>5 log IU/ml), without cirrhosis and overt diabetes, were enrolled… CONTINUE READING