Impact of alpha-bungarotoxin on transmitter release at the neuromuscular junction of the rat.

@article{Domet1995ImpactOA,
  title={Impact of alpha-bungarotoxin on transmitter release at the neuromuscular junction of the rat.},
  author={M A Domet and Cameron Ewart Webb and David F Wilson},
  journal={Neuroscience letters},
  year={1995},
  volume={199 1},
  pages={49-52}
}
The drug, alpha-bungarotoxin (BTX) is believed to be a 'pure' nicotinic antagonist. Hence, use of this drug should avoid the secondary actions associated with other nicotinic antagonists. The hypothesis that the motor nerve terminal responds to the presence of acetylcholine (ACh) by releasing less transmitter was tested by examining the effects of BTX on end-plate potentials (EPPs), miniature end-plate potentials (MEPPs), and quantal release at the rat diaphragm neuromuscular junction. Analysis… CONTINUE READING