Impact of allele-level HLA matching on outcomes after myeloablative single unit umbilical cord blood transplantation for hematologic malignancy.

Abstract

We studied the effect of allele-level matching at human leukocyte antigen (HLA)-A, -B, -C, and -DRB1 in 1568 single umbilical cord blood (UCB) transplantations for hematologic malignancy. The primary end point was nonrelapse mortality (NRM). Only 7% of units were allele matched at HLA-A, -B, -C, and -DRB1; 15% were mismatched at 1, 26% at 2, 30% at 3, 16… (More)
DOI: 10.1182/blood-2013-05-506253

Topics

6 Figures and Tables

Cite this paper

@article{Eapen2014ImpactOA, title={Impact of allele-level HLA matching on outcomes after myeloablative single unit umbilical cord blood transplantation for hematologic malignancy.}, author={Mary Eapen and John P. Klein and Annalisa Ruggeri and Stephen R. Spellman and Stephanie J Lee and Claudio Anasetti and William Arcese and Juliet N. Barker and Lee Ann Baxter-Lowe and Maria C Brown and Marcelo An{\'i}bal Fern{\'a}ndez-Vi{\~n}a and John F. Freeman and Wensheng He and Anna Paola Iori and Mary Horowitz and Franco Locatelli and Susana R. Marino and Martin Maiers and G{\'e}rard Michel and Guillermo F. Sanz and Eliane Gluckman and Vanderson Geraldo Rocha}, journal={Blood}, year={2014}, volume={123 1}, pages={133-40} }