Impact of aging on hippocampal function: plasticity, network dynamics, and cognition

@article{Rosenzweig2003ImpactOA,
  title={Impact of aging on hippocampal function: plasticity, network dynamics, and cognition},
  author={Ephron S Rosenzweig and Carol A. Barnes},
  journal={Progress in Neurobiology},
  year={2003},
  volume={69},
  pages={143-179}
}
Integrity of mGluR-LTD in the Associative/Commissural Inputs to CA3 Correlates with Successful Aging in Rats
TLDR
It is found that, unlike in CA1 synapses, in A/C→CA3 LTP is minimally affected by age, but two forms of LTD, involving NMDA and metabotropic glutamate receptors (mGluR), are both greatly reduced in age-impaired rats.
Potential Adaptive Function for Altered Long-Term Potentiation Mechanisms in Aging Hippocampus
TLDR
It is found that age substantially reduces NMDAR-dependent LTP across the spectrum of cognitive outcomes, whereas increased NMDar-independent LTP occurs distinctively in high-performing aged rats.
The effects of aging on dentate circuitry and function.
Modulators of synaptic plasticity in the hippocampus
TLDR
It is shown that supplementing aged mice with a precursor for GSH formation reverses the mechanisms underlying hippocampal LTP from L-type calcium channel dependence back to NMDA receptor-dependence, suggesting an important role for GSI as a modulator of synaptic plasticity in aging.
Involvement of BDNF in Age-Dependent Alterations in the Hippocampus
  • O. Halbach
  • Biology, Psychology
    Front. Ag. Neurosci.
  • 2010
TLDR
It is hypothesized that brain-derived neurotrophic factor (BDNF) is a factor critically involved in the regulation of age-related processes in the hippocampus, and evidences suggest that disturbances in the BDNF-system also affect hippocampal dysfunctions, as e.g. seen in major depression or in Alzheimer disease.
Age‐related alterations in hippocampal spines and deficiencies in spatial memory in mice
TLDR
It is suggested that the memory and cognitive decline in the context of aging may be accompanied by rather subtle anatomical changes, such as numbers and morphology of dendritic spines.
Region-Specific Genetic Alterations in the Aging Hippocampus: Implications For Cognitive Aging
TLDR
This review discusses the relationship between region-specific hippocampal connectivity, morphology, and gene expression alterations and the cognitive deficits associated with senescence in the CA1, CA3, and dentate gyrus.
Stem-cell-associated structural and functional plasticity in the aging hippocampus.
TLDR
One promising avenue to reach the goal of successful aging might be to boost and recruit this plasticity, which is the interplay between neural structure, function, and experience, to prevent age-related cognitive decline and age-associated comorbidities.
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