Impact of aging on heat shock protein expression in the substantia nigra and striatum of the female rat

@article{Gleixner2014ImpactOA,
  title={Impact of aging on heat shock protein expression in the substantia nigra and striatum of the female rat},
  author={Amanda Marie Gleixner and Sree H Pulugulla and D Badridatt Pant and Jessica M Posimo and Tyler S Crum and Rehana K Leak},
  journal={Cell and Tissue Research},
  year={2014},
  volume={357},
  pages={43-54}
}
Many heat shock proteins are chaperones that help refold or degrade misfolded proteins and battle apoptosis. Because of their capacity to protect against protein misfolding, they may help keep diseases of aging at bay. A few reports have examined heat shock proteins (eg. Hsp25, Hsp60, Hsp70, and heat shock cognate 70 or Hsc70) as a function of age in the striatum and nigra. In the present study, we examined the impact of aging on Hsp25, heme oxygenase 1 (HO1 or Hsp32), Hsp40, Hsp60, Hsc70, Hsc… CONTINUE READING
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