Impact of aging on dendritic cell functions in humans.

  title={Impact of aging on dendritic cell functions in humans.},
  author={Anshu Agrawal and Sudhir Gupta},
  journal={Ageing research reviews},
  volume={10 3},
Aging is a paradox of reduced immunity and chronic inflammation. Dendritic cells are central orchestrators of the immune response with a key role in the generation of immunity and maintenance of tolerance. The functions of DCs are compromised with age. There is no major effect on the numbers and phenotype of DC subsets in aged subjects; nevertheless, their capacity to phagocytose antigens and migrate is impaired with age. There is aberrant cytokine secretion by various DC subsets with CDCs… CONTINUE READING