Impact of age on T cell signaling: a general defect or specific alterations?

@article{Larbi2011ImpactOA,
  title={Impact of age on T cell signaling: a general defect or specific alterations?},
  author={Anis Larbi and Graham P Pawelec and Siew Cheng Wong and David Goldeck and June Jing-Yi Tai and Tamas Z Fulop},
  journal={Ageing research reviews},
  year={2011},
  volume={10 3},
  pages={370-8}
}
Decreased immune responsiveness associated with aging is generally termed "immunosenescence". Several theories have been proposed to explain age-related declines in immune responses. Here, we will focus on and describe potential defects in T cell signal transduction from the membrane to the nucleus, leading to changes in the type, intensity and duration of the response as a major factor contributing to immunosenescence. We will first detail T cell signaling through the T cell receptor (TCR… CONTINUE READING
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