Impact of age, gender and CYP2C9/2C19 genotypes on dose-adjusted steady-state serum concentrations of valproic acid—a large-scale study based on naturalistic therapeutic drug monitoring data

Abstract

Valproic acid (VPA) has an extensive interindividual pharmacokinetic variability. Published data regarding the impact of gender, age, and CYP2C9/2C19 genetics on VPA variability are conflicting, and the purpose of present study is to clarify the effect of these factors on dose-adjusted steady-state serum VPA concentration (C:D ratio) in a large… (More)
DOI: 10.1007/s00228-016-2087-0

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@article{Smith2016ImpactOA, title={Impact of age, gender and CYP2C9/2C19 genotypes on dose-adjusted steady-state serum concentrations of valproic acid—a large-scale study based on naturalistic therapeutic drug monitoring data}, author={R. L. Smith and Tore Haslemo and Helge Refsum and Erin Molden}, journal={European Journal of Clinical Pharmacology}, year={2016}, volume={72}, pages={1099-1104} }