Impact of aberrant methylation of microRNA-9 family members on non-small cell lung cancers.

@article{Muraoka2013ImpactOA,
  title={Impact of aberrant methylation of microRNA-9 family members on non-small cell lung cancers.},
  author={Takayuki Muraoka and Junichi Soh and Shinichi Toyooka and Yuho Maki and Kazuhiko Shien and Masashi Furukawa and Tsuyoshi Ueno and Norimitsu Tanaka and Hiromasa Yamamoto and Hiroaki Asano and Kazunori Tsukuda and Shinichiro Miyoshi},
  journal={Molecular and clinical oncology},
  year={2013},
  volume={1 1},
  pages={185-189}
}
MicroRNAs (miRs) contribute to cancer development and progression by acting as oncogenes and tumor suppressor genes. miR-9 family members (miR-9s), including miR-9-1, 9-2 and 9-3, have been shown to be oncogenically involved through the downregulation of E-cadherin expression, which promotes the epithelial-mesenchymal transition. Tumor suppressive roles of miR-9s have also been reported to silence miR-9 through methylation, which is associated with an shortened overall survival (OS) period in… CONTINUE READING
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Cancer statistics Molecular oncology of lung cancer

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