Impact of a synthetic cannabinoid (CP-47,497-C8) on protein expression in human cells: evidence for induction of inflammation and DNA damage

@article{Bileck2015ImpactOA,
  title={Impact of a synthetic cannabinoid (CP-47,497-C8) on protein expression in human cells: evidence for induction of inflammation and DNA damage},
  author={Andrea Bileck and Franziska Ferk and Halh Al-Serori and Verena Juliana Koller and Besnik Muqaku and Alexander G Haslberger and Volker Auw{\"a}rter and Christopher Gerner and Siegfried Knasm{\"u}ller},
  journal={Archives of Toxicology},
  year={2015},
  volume={90},
  pages={1369-1382}
}
Synthetic cannabinoids (SCs) are marketed worldwide as legal surrogates for marihuana. In order to predict potential health effects in consumers and to elucidate the underlying mechanisms of action, we investigated the impact of a representative of the cyclohexylphenols, CP47,497-C8, which binds to both cannabinoid receptors, on protein expression patterns, genomic stability and on induction of inflammatory cytokines in human lymphocytes. After treatment of the cells with the drug, we found… 
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