Impact of a molecular approach to improve the microbiological diagnosis of infective heart valve endocarditis.

@article{Breitkopf2005ImpactOA,
  title={Impact of a molecular approach to improve the microbiological diagnosis of infective heart valve endocarditis.},
  author={Claudia Breitkopf and Dieter Hammel and Hans Heinrich Scheld and Georg Peters and Karsten Becker},
  journal={Circulation},
  year={2005},
  volume={111 11},
  pages={1415-21}
}
BACKGROUND Even today, infective endocarditis (IE) remains a severe and potentially fatal disease demanding sophisticated diagnostic strategies for detection of the causative microorganisms. Despite the use of appropriate laboratory techniques, classic microbiological diagnostics are characterized by a high rate of negative results. METHODS AND RESULTS Broad-range polymerase chain reaction (PCR) targeting bacterial and fungal rDNA followed by direct sequencing was applied to excised heart… CONTINUE READING

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A broad-range PCR technique for the diagnosis of infective endocarditis

Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] • 2018

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