Impact of a hospital-wide programme of heterogeneous antibiotic use on the development of antibiotic-resistant Gram-negative bacteria.

@article{Takesue2010ImpactOA,
  title={Impact of a hospital-wide programme of heterogeneous antibiotic use on the development of antibiotic-resistant Gram-negative bacteria.},
  author={Yoshio Takesue and Kazuhiko Nakajima and Kaoru Ichiki and Mika Ishihara and Yasunao Wada and Yoshiko Takahashi and Toshie Tsuchida and Hiroki Ikeuchi},
  journal={The Journal of hospital infection},
  year={2010},
  volume={75 1},
  pages={28-32}
}
Although antibiotic heterogeneity has been proposed as a strategy to limit the emergence of antibiotic resistance, few clinical studies have been conducted to validate the concept. This paper evaluates a hospital-wide strategy of heterogeneous antibiotic use intended to reduce infections caused by resistant Gram-negative rods (GNR). A strategy termed 'periodic antimicrobial monitoring and supervision' (PAMS) was implemented between September 2006 and February 2008. The 18 month intervention… CONTINUE READING

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