Impact of a glycogen phosphorylase inhibitor and metformin on basal and glucagon-stimulated hepatic glucose flux in conscious dogs.

@article{Torres2011ImpactOA,
  title={Impact of a glycogen phosphorylase inhibitor and metformin on basal and glucagon-stimulated hepatic glucose flux in conscious dogs.},
  author={Tracy P. Torres and Noriyasu Sasaki and E. Patrick Donahue and Brooks Lacy and Richard L. Printz and Alan D. Cherrington and Judith L. Treadway and Masakazu Shiota},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2011},
  volume={337 3},
  pages={610-20}
}
The effects of a glycogen phosphorylase inhibitor (GPI) and metformin (MT) on hepatic glucose fluxes (μmol · kg(-1) · min(-1)) in the presence of basal and 4-fold basal levels of plasma glucagon were investigated in 18-h fasted conscious dogs. Compared with the vehicle treatment, GPI infusion suppressed net hepatic glucose output (NHGO) completely (-3.8 ± 1.3 versus 9.9 ± 2.8) despite increased glucose 6-phosphate (G-6-P) neogenesis from gluconeogenic precursors (8.1 ± 1.1 versus 5.5 ± 1.1). MT… CONTINUE READING

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