Impact of a Panel of 88 Single Nucleotide Polymorphisms on the Risk of Breast Cancer in High-Risk Women: Results From Two Randomized Tamoxifen Prevention Trials

@inproceedings{Cuzick2017ImpactOA,
  title={Impact of a Panel of 88 Single Nucleotide Polymorphisms on the Risk of Breast Cancer in High-Risk Women: Results From Two Randomized Tamoxifen Prevention Trials},
  author={Jack Cuzick and Adam R. Brentnall and Corrinne V Segal and Helen Byers and Caroline H. Reuter and Simone I Detre and Elena L{\'o}pez-Knowles and Ivana Sestak and Anthony Howell and Trevor J. Powles and William G. Newman and Mitchell Dowsett},
  booktitle={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={2017}
}
Purpose At least 94 common single nucleotide polymorphisms (SNPs) are associated with breast cancer. The extent to which an SNP panel can refine risk in women who receive preventive therapy has not been directly assessed previously. Materials and Methods A risk score on the basis of 88 SNPs (SNP88) was investigated in a nested case-control study of women enrolled in the International Breast Intervention Study (IBIS-I) or the Royal Marsden study. A total of 359 women who developed cancer were… CONTINUE READING
8 Citations
40 References
Similar Papers

Citations

Publications citing this paper.

References

Publications referenced by this paper.
Showing 1-10 of 40 references

moxifen for prevention of breast cancer : Extended long - term follow - up of the IBISI breast cancer prevention trial

  • TJ Powles, S Ashley, A Tidy
  • Lancet Oncol
  • 2015

Similar Papers

Loading similar papers…