Impact of Vitamin D in the Treatment of Tuberculosis

  title={Impact of Vitamin D in the Treatment of Tuberculosis},
  author={Khanh vinh quốc Lương and Lan Thị H{\`o}ang Nguyễn},
  journal={The American Journal of the Medical Sciences},
  • K. Lương, L. Nguyễn
  • Published 1 June 2011
  • Medicine, Biology
  • The American Journal of the Medical Sciences
Tuberculosis (TB) is a major global health problem and often coincides with nutritional deficiency. In fact, vitamin D deficiency has been reported among TB patients, and vitamin D receptor polymorphisms are associated with susceptibility to Mycobacterium tuberculosis. High doses of vitamin D were widely used to treat TB patients in the preantibiotic era. This approach was successful: vitamin D can suppress intracellular growth of M tuberculosis in vitro. Vitamin D also induced the expression… 
Impact of Vitamin D in Prophylaxis and Treatment in Tuberculosis Patients
It would be advisable to assess vitamin D level both in patients with active TB and high-risk groups and administer it, at least to reach sufficiency levels, considering the low incidence of side effects even at high dosages and its low cost.
Vitamin D and tuberculosis
The role that vitamin D plays in tuberculosis has also been demonstrated by its effects on Bacillus Calmette Guerin, vascular endothelial growth factor, matrix metalloproteinases, prostaglandins, reactive oxygen species, and reactive nitrogen intermediates, in addition to its synergistic effects with some anti-tuberculosis medications.
Potential Role of Vitamins A, B, C, D and E in TB Treatment and Prevention: A Narrative Review
Vitamin supplementation as a prophylactic measure in those who are at high risk of Mycobacterium tuberculosis (MTB) infection and active TB is suggested and the use of vitamins in TB patients is encouraged.
Estimation of some Immunological Factors in Pulmonary Tuberculosis Patients
A good correlation between the levels of IL-10 , IL-12, IFN-γ and Vitamin D3 with the cellular immunity against pulmonary tuberculosis is provided.
Vitamin D in Oncology
  • J. Arends
  • Medicine, Biology
    Complementary Medicine Research
  • 2011
While supplements of vitamin D improve musculoskeletal symptoms, proof is still lacking that these doses convey a protection from cancer, Interventional studies that administer vitamin D versus placebo in patients with cancer should be a high priority.
The effects of first-line anti-tuberculosis drugs on the actions of vitamin D in human macrophages
Vitamin D status in pediatric osteoarticular tuberculosis.
Influence of vitamin D deficiency on T cell subsets and related indices during spinal tuberculosis
The expression of T lymphocyte subsets in patients with vitamin D deficiency was significantly reduced, and the immune function decreased, which was not conducive to the recovery of tuberculosis lesions.
Avaliação das concentrações de vitamina D associadas a polimorfismos em genes ligados a resposta imune durante a tuberculose pulmonar ativa
Evidence is provided of the association between VDR SNPs and Gc-globulin and serum of 25(OH)D how possible protective factors against TB and also susceptibility in Brazilian population.
Prevalence of vitamin D deficiency in adults in the coastal regions of Odisha, India
Regular serum vitamin D status must be assessed to review the nutritional status in apparently healthy population and in musculoskeletal diseases, suggesting that Vitamin D supplementation may be introduced along with regular monitoring may be included in the health care management.


Vitamin D as Adjunctive Therapy in Refractory Pulmonary Tuberculosis: A Case Report
A case of vitamin D deficiency in a woman with refractory drug-susceptible PTB is presented and antituberculous therapy and the correction ofitamin D deficiency resulted in clinical and microbiologic improvement at month 13 of her treatment.
Reactivation of tuberculosis and vitamin D deficiency: the contribution of diet and exposure to sunlight
Patients with active TB have lower serum vitamin D concentrations than contacts from similar ethnic and social backgrounds and with comparable dietary intake and sun exposure, and do not show the expected seasonal variation.
Vitamin D Deficiency and Tuberculosis Progression
Vitamin D levels in a cohort of tuberculosis patients and their contacts in Pakistan showed low vitamin D levels were associated with a 5-fold increased risk for progression to tuberculosis.
Meta-analysis of vitamin D receptor polymorphisms and pulmonary tuberculosis risk.
  • S. Lewis, I. Baker, G. Davey Smith
  • Biology, Medicine
    The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease
  • 2005
A systematic review and meta-analysis of case-control studies performed in populations where the incidence of tuberculosis (TB) is high found that results were inconclusive and studies were underpowered.
Vitamin D deficiency is associated with tuberculosis and latent tuberculosis infection in immigrants from sub-Saharan Africa.
  • K. Gibney, L. MacGregor, B. Biggs
  • Medicine
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
  • 2008
Among African immigrants in Melbourne, Victoria, Australia, we demonstrated lower geometric mean vitamin D levels in immigrants with latent tuberculosis infection than in those with no Mycobacterium
Tuberculosis and chronic hepatitis B virus infection in Africans and variation in the vitamin D receptor gene.
Variation in the vitamin D receptor gene was typed in 2015 subjects from large case-control studies of three major infectious diseases: tuberculosis, malaria, and hepatitis B virus, and homozygotes for a polymorphism at codon 352 (genotype tt) were significantly underrepresented.
Vitamin D as supplementary treatment for tuberculosis: a double-blind, randomized, placebo-controlled trial.
Vitamin D does not improve clinical outcome among patients with tuberculosis and the trial showed no overall effect on mortality in patients with TB; it is possible that the dose used was insufficient.
The effect of vitamin D as supplementary treatment in patients with moderately advanced pulmonary tuberculous lesion.
The sputum conversion had no correlation with the hemoglobin level, blood clotting time, calcium level, lymphocyte count, age, sex, and nutritional status, and there were more subjects with radiological improvement in the vitamin D group.
The effect of multi-vitamin/mineral supplementation on mortality during treatment of pulmonary tuberculosis: a randomised two-by-two factorial trial in Mwanza, Tanzania.
Benefits of supplementation with MVM, including Zn, during treatment of pulmonary TB may reduce mortality in those co-infected with HIV, and a randomised trial of the effect of the combined intervention used in this study should be conducted in a different setting to confirm the finding.