Impact of Vitamin D in the Treatment of Tuberculosis

@article{Lng2011ImpactOV,
  title={Impact of Vitamin D in the Treatment of Tuberculosis},
  author={Khanh vinh quốc Lương and Lan Thị H{\`o}ang Nguyễn},
  journal={The American Journal of the Medical Sciences},
  year={2011},
  volume={341},
  pages={493-498}
}
Tuberculosis (TB) is a major global health problem and often coincides with nutritional deficiency. In fact, vitamin D deficiency has been reported among TB patients, and vitamin D receptor polymorphisms are associated with susceptibility to Mycobacterium tuberculosis. High doses of vitamin D were widely used to treat TB patients in the preantibiotic era. This approach was successful: vitamin D can suppress intracellular growth of M tuberculosis in vitro. Vitamin D also induced the expression… 
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The expression of T lymphocyte subsets in patients with vitamin D deficiency was significantly reduced, and the immune function decreased, which was not conducive to the recovery of tuberculosis lesions.
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Background and objectives: Vitamin D is a fat-soluble vitamin belonging to secosteriods. It is responsible for intestinal absorption and bioavailibity of calcium and phosphorus.Synthesisof vitamin D
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It is reasonable to postulate that vitamin D supplementation being a cost effective and relative simple procedure may benefit to liver fibrosis, but further research is needed to fully elucidate its regulatory role in inhibiting liver fibrogenesis.
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This review discusses examples of potentially promising strategies aimed at improving the host response to M. tuberculosis, and argues how a better understanding of TB pathogenesis may pave the way for the design of new therapies, the identification of new drugs or the repurposing of some already in use for other diseases.
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TLDR
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