Impact of Vitamin C Supplementation on Post-Cardiac Surgery ICU and Hospital Length of Stay
@article{Sadeghpour2015ImpactOV, title={Impact of Vitamin C Supplementation on Post-Cardiac Surgery ICU and Hospital Length of Stay}, author={Anita Sadeghpour and Azin Alizadehasl and Majid Kyavar and Tahereh Sadeghi and Jalal Moludi and Farhad Gholizadeh and Ziae Totonchi and Behshid Ghadrdoost}, journal={Anesthesiology and Pain Medicine}, year={2015}, volume={5} }
Background: Prolonged intensive care unit (ICU) and hospital stay after cardiac surgery is vitally important and is influenced by both intraoperative and postoperative factors. Objectives: This randomized clinical trial study was designed to assess whether vitamin C supplementation could reduce the length of ICU and hospital stay in post-cardiac surgery patients. Patients and Methods: Two hundred and ninety patients scheduled for adult cardiac surgery including coronary, valve and congenital…
34 Citations
Vitamin C Can Shorten the Length of Stay in the ICU: A Meta-Analysis
- MedicineNutrients
- 2019
Evaluating whether vitamin C has an effect on the practical outcomes: length of stay in the intensive care unit (ICU) and duration of mechanical ventilation found that even an 8% reduction in ICU stay is worth exploring.
Effects of Vitamin C on Organ Function in Cardiac Surgery Patients: A Systematic Review and Meta-Analysis
- MedicineNutrients
- 2019
This meta-analysis cannot answer the question, if vitamin C can improve single- or multiorgan function after cardiac surgery, but impacts clinically and economically important outcomes, such as ICU and hospital length-of-stay, duration of mechanical ventilation and lowers the incidence of atrial fibrillation.
The Effect of Vitamin C Supplementation on Cardiac Enzymes After Coronary Artery Bypass Graft: A Double-blind Randomized Control Trial
- Medicine
- 2020
Pretreatment with vitamin C as an antioxidant agent could not reduce ischemicreperfusion resulting in CABG and the correlation between cardiac enzymes and surgical characteristic was not seen.
Vitamin C supplementation in the critically ill: A systematic review and meta-analysis
- MedicineSAGE open medicine
- 2018
The administration of intravenous vitamin C may lead to vasopressor sparing effects and a reduced need for mechanical ventilation in the critically ill, without affecting overall mortality.
Efficacy and safety of vitamin C for atrial fibrillation after cardiac surgery: A meta-analysis with trial sequential analysis of randomized controlled trials.
- MedicineInternational journal of surgery
- 2017
Vitamin C may reduce the duration of mechanical ventilation in critically ill patients: a meta-regression analysis
- MedicineJournal of Intensive Care
- 2020
Strong evidence is found that vitamin C shortens the length of mechanical ventilation, but the magnitude of the effect seems to depend on the duration of ventilation in the untreated control group.
Vitamin C to Improve Organ Dysfunction in Cardiac Surgery Patients—Review and Pragmatic Approach
- Medicine, BiologyNutrients
- 2018
This review covers current knowledge about the role of vitamin C in cardiac surgery patients with focus on its influence on organ dysfunctions, and the relationships between vitamin C and clinical health outcomes are reviewed.
The clinical benefits of perioperative antioxidant vitamin therapy in patients undergoing cardiac surgery: a meta-analysis.
- MedicineInteractive cardiovascular and thoracic surgery
- 2017
It is demonstrated that perioperative antioxidant vitamin therapy in patients undergoing cardiac surgery can reduce the incidence of POAF, duration of hospital stay, intensive care unit length of stay and intubation time.
Effect of vitamin C and vitamin E on lung contusion: A randomized clinical trial study
- MedicineAnnals of medicine and surgery
- 2018
Meta-analysis of ascorbic acid for prevention of postoperative atrial fibrillation after cardiac surgery.
- MedicineAmerican journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists
- 2016
A meta-analysis revealed that, compared with use of a placebo or a nonplacebo control, perioperative administration of ascorbic acid to patients undergoing cardiac surgery was associated with a reduced frequency of POAF and a shorter ICU LOS and total hospital LOS.
References
SHOWING 1-10 OF 19 REFERENCES
Effect of oral vitamin C on atrial fibrillation development after isolated coronary artery bypass grafting surgery: A prospective randomized clinical trial.
- MedicineCardiology journal
- 2014
Oral vitamin C can be safely used to decrease the incidence of postoperative AF in patients undergoing elective isolated on-pump CABG surgery.
Risk factors for prolonged stay in cardiac surgery intensive care units.
- MedicineNursing in critical care
- 2011
Increased level of NWL and patient perioperative risk are closely associated with increased ICU-LOS and encourages the early identification of high-risk patients for prolonged hospitalization with the use of an independent nursing tool.
Prolonged intensive care unit stay in cardiac surgery: risk factors and long-term-survival.
- MedicineThe Annals of thoracic surgery
- 2006
Effect of vitamin C on morphine use after laparoscopic cholecystectomy: a randomized controlled trial
- Medicine, Computer ScienceCanadian Journal of Anesthesia/Journal canadien d'anesthésie
- 2012
It was showed that supplementation with vitamin C (2 g) po decreased morphine consumption in the postoperative period in patients undergoing laparoscopic cholecystectomy.
Randomized, Prospective Trial of Antioxidant Supplementation in Critically Ill Surgical Patients
- MedicineAnnals of surgery
- 2002
The early administration of antioxidant supplementation using &agr;-tocopherol and ascorbic acid reduces the incidence of organ failure and shortens ICU length of stay in this cohort of critically ill surgical patients.
Determinants of prolonged length of hospital stay after coronary bypass surgery.
- MedicineCirculation
- 1989
The length of hospital stay after coronary surgery was studied in patients undergoing cardiac catheterization followed by coronary surgery at Emory University Hospital or Crawford Long Hospital and was correlated with the periprocedural variables of wound infection, neurologic event, arrhythmias, pneumonia, postoperative myocardial infarction, mortality, and pericarditis.
A randomized controlled trial to prevent post-operative atrial fibrillation by antioxidant reinforcement.
- MedicineJournal of the American College of Cardiology
- 2013
Prediction of Prolonged Length of Stay in the Intensive Care Unit After Cardiac Surgery: The Need for a Multi‐institutional Risk Scoring System
- MedicineJournal of cardiac surgery
- 2009
There is a need for the development of a uniform multi‐institutional risk scoring system for prolonged ICU LOS following cardiac surgery, which could aid in quality assessment, practice improvement, patient counseling, and decision making.
Oral ascorbic acid in combination with beta-blockers is more effective than beta-blockers alone in the prevention of atrial fibrillation after coronary artery bypass grafting.
- MedicineTexas Heart Institute journal
- 2007
It is concluded that ascorbic acid is effective, in addition to being well-tolerated and relatively safe, and can be prescribed as an adjunct to beta-blockers for the prophylaxis of post-bypass atrial fibrillation.
Morbidity and duration of ICU stay after cardiac surgery. A model for preoperative risk assessment.
- MedicineChest
- 1992
It is demonstrated that it is feasible to design a simple method to stratify the risk of serious morbidity after adult cardiac surgery and is likely to be useful for adjusting severity of illness when reporting outcome statistics as well as planning resource utilization.