Impact of UGT1A1 genotype upon toxicities of combination with low-dose irinotecan plus platinum.

@article{Takano2016ImpactOU,
  title={Impact of UGT1A1 genotype upon toxicities of combination with low-dose irinotecan plus platinum.},
  author={Masashi Takano and Kaichiro Yamamoto and Tsutomu Tabata and Yuji Minegishi and Takuma Yokoyama and Eiji Hirata and Takeshi Ikeda and Muneaki Shimada and Kouzo Yamada and Satoshi Morita and Yuichi Ando and Koji Hirata and Masahiro Sugihara and Toru Sugiyama and Yasuo Ohashi and Yuh Sakata},
  journal={Asia-Pacific journal of clinical oncology},
  year={2016},
  volume={12 2},
  pages={115-24}
}
AIM Irinotecan-induced severe toxicities are possibly related to UGT1A1*6 and *28 genotypes. However, the correlation between UGT1A1 polymorphisms and the risk of toxicities induced by low-dose irinotecan plus platinum combination therapy still remains controversial. This prospective observational study aimed to examine the correlation between UGT1A1… CONTINUE READING