Impact of Type 2 diabetes and aging on cardiomyocyte function and O-linked N-acetylglucosamine levels in the heart.

@article{Flp2007ImpactOT,
  title={Impact of Type 2 diabetes and aging on cardiomyocyte function and O-linked N-acetylglucosamine levels in the heart.},
  author={Norbert F{\"u}l{\"o}p and Meredith M Mason and Kaushik Dutta and Peipei Wang and Amy J Davidoff and Richard B. Marchase and John C Chatham},
  journal={American journal of physiology. Cell physiology},
  year={2007},
  volume={292 4},
  pages={C1370-8}
}
Increased levels of O-linked attachment of N-acetylglucosamine (O-GlcNAc) on nucleocytoplasmic proteins are implicated in the development of diabetic cardiomyopathy and are regulated by O-GlcNAc transferase (OGT) expression and its substrate UDP-GlcNAc. Therefore, the goal of this study was to determine whether the development of diabetes in the Zucker diabetic fatty (ZDF) rat, a model of Type 2 diabetes, results in defects in cardiomyocyte mechanical function and, if so, whether this is… CONTINUE READING

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