Impact of Tumor Purity on Immune Gene Expression and Clustering Analyses across Multiple Cancer Types.

@article{Rhee2018ImpactOT,
  title={Impact of Tumor Purity on Immune Gene Expression and Clustering Analyses across Multiple Cancer Types.},
  author={Je-keun Rhee and Yu Chae Jung and Kyu Ryung Kim and Jinseon Yoo and Jeeyoon Kim and Yong Jae Lee and Yoon Ho Ko and Han Hong Lee and Byoung Chul Cho and Tae-Min Kim},
  journal={Cancer immunology research},
  year={2018},
  volume={6 1},
  pages={87-97}
}
Surgical archives of tumor specimens are often impure. The presence of RNA transcripts from nontumor cells, such as immune and stromal cells, can impede analyses of cancer expression profiles. To systematically analyze the impact of tumor purity, the gene expression profiles and tumor purities were obtained for 7,794 tumor specimens across 21 tumor types… CONTINUE READING