• Chemistry, Medicine
  • Published in
    Environmental health…
    2006
  • DOI:10.1289/ehp.9440

Impact of Trivalent Arsenicals on Selenoprotein Synthesis

@inproceedings{Ganyc2006ImpactOT,
  title={Impact of Trivalent Arsenicals on Selenoprotein Synthesis},
  author={Denis Ganyc and Sarah Talbot and Fanta Konate and Sarah Jackson and Brian C. Schanen and W. Rod Cullen and William Thomas Self},
  booktitle={Environmental health perspectives},
  year={2006}
}
BACKGROUND Exposure to arsenic has been associated with development of skin, lung, bladder, liver, and kidney cancer. Recent evidence suggests that an increase in oxidative stress in cells treated with arsenicals represents the molecular mechanism behind arsenic-induced carcinogenesis. Selenium, in the form of selenocysteine, is necessary for the activity of several enzymes with a role in defense against reactive oxygen species. A mutual sparing effect between arsenic and selenium has been… CONTINUE READING

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