Impact of Spironolactone on Longitudinal Changes in Health-Related Quality of Life in the Treatment of Preserved Cardiac Function Heart Failure With an Aldosterone Antagonist Trial.

@article{Lewis2016ImpactOS,
  title={Impact of Spironolactone on Longitudinal Changes in Health-Related Quality of Life in the Treatment of Preserved Cardiac Function Heart Failure With an Aldosterone Antagonist Trial.},
  author={Eldrin F. Lewis and Hae-Young Kim and Brian Lee Claggett and John A Spertus and John F. Heitner and Susan F. Assmann and Christopher T Kenwood and Scott Solomon and Akshay S. Desai and James Chen-Tson Fang and Sonia A McKinlay and Bertram A Pitt and Marc Pfeffer},
  journal={Circulation. Heart failure},
  year={2016},
  volume={9 3},
  pages={e001937}
}
BACKGROUND Heart failure (HF) with preserved ejection fraction patients have equally impaired health-related quality of life (HRQL) compared with those with HF with reduced ejection fraction, but limited studies have evaluated the impact of therapies on changes in HRQL. METHODS AND RESULTS Patients ≥50 years of age, with symptomatic HF and left ventricular ejection fraction ≥45%, were enrolled in Treatment of Preserved Cardiac Function Heart Failure With an Aldosterone Antagonist (TOPCAT) and… CONTINUE READING
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