Impact of Smad3 loss of function on scarring and adhesion formation during tendon healing.

@article{Katzel2011ImpactOS,
  title={Impact of Smad3 loss of function on scarring and adhesion formation during tendon healing.},
  author={Evan B Katzel and Matthew Wolenski and Alayna E Loiselle and Patrick Basile and Lisa M. Flick and Howard N. Langstein and Matthew J Hilton and Hani A Awad and Warren C. Hammert and Regis J O'keefe},
  journal={Journal of orthopaedic research : official publication of the Orthopaedic Research Society},
  year={2011},
  volume={29 5},
  pages={684-93}
}
Studies were performed evaluating the role of Smad3, a transcription factor mediating canonical TGF-β signaling, on scarring and adhesion formation using an established flexor digitorum longus (FDL) tendon repair model. In unoperated animals the metatarsophalangeal (MTP) range of motion (ROM) was similar in Smad3(-/-) and wild-type (WT) mice while the basal tensile strength of Smad3(-/-) tendons was significantly (39%) lower than in WT controls. At 14 and 21 days following repair Smad3(-/-) MTP… CONTINUE READING
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