Impact of Sim1 gene dosage on the development of the paraventricular and supraoptic nuclei of the hypothalamus.

@article{Duplan2009ImpactOS,
  title={Impact of Sim1 gene dosage on the development of the paraventricular and supraoptic nuclei of the hypothalamus.},
  author={Sabine Micha{\"e}lle Duplan and Francine Boucher and Lubomir Alexandrov and Jacques L. Michaud},
  journal={The European journal of neuroscience},
  year={2009},
  volume={30 12},
  pages={2239-49}
}
The bHLH-PAS transcription SIM1 is required for the development of all neurons of the paraventricular nucleus (PVN) and supraoptic nucleus (SON) of the hypothalamus. Mice with a loss of Sim1 die within a few days of birth, presumably because of the lack of a PVN and SON. In contrast, mice with a decrease of Sim1 survive, are hyperphagic and become obese. The mechanism by which Sim1 controls food intake remains unclear. Here we show that the development of specific PVN and SON cell types is… CONTINUE READING