Impact of SRC homology 2-containing inositol 5'-phosphatase 2 gene polymorphisms detected in a Japanese population on insulin signaling.

@article{Kagawa2005ImpactOS,
  title={Impact of SRC homology 2-containing inositol 5'-phosphatase 2 gene polymorphisms detected in a Japanese population on insulin signaling.},
  author={Syota Kagawa and Toshiyasu Sasaoka and Saori Yaguchi and Hajime Ishihara and Hiroshi Tsuneki and Shihou Murakami and Kazuhito Fukui and Tsutomu Wada and Soushi Kobayashi and Ikuko Kimura and Masashi Kobayashi},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2005},
  volume={90 5},
  pages={2911-9}
}
Src homology 2-containing 5'-inositol phosphatase 2 (SHIP2) is known to be one of lipid phosphatases converting PI(3,4,5)P3 to PI(3,4)P2 in the negative regulation of insulin signaling with the fundamental impact on the state of insulin resistance. To clarify the possible involvement of SHIP2 in the pathogenesis of human type 2 diabetes, we examined the relation of human SHIP2 gene polymorphisms to type 2 diabetes in a Japanese population. We identified 10 polymorphisms including four missense… CONTINUE READING
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