Impact of SNPs on methylation readouts by Illumina Infinium HumanMethylation450 BeadChip Array: implications for comparative population studies

@article{DacaRoszak2015ImpactOS,
  title={Impact of SNPs on methylation readouts by Illumina Infinium HumanMethylation450 BeadChip Array: implications for comparative population studies},
  author={P. Daca-Roszak and Aleksandra Pfeifer and Jadwiga Żebracka‐Gala and Dagmara Rusinek and Aleksandra Szybińska and Barbara Jarzab and Michał Witt and Ewa Ziętkiewicz},
  journal={BMC Genomics},
  year={2015},
  volume={16}
}
BackgroundInfinium HumanMethylation 450 BeadChip Arrays by Illumina (Illumina HM450K) are among the most popular CpG microarray platforms widely used in biological and medical research. Several recent studies highlighted the potentially confounding impact of the genomic variation on the results of methylation studies performed using Illumina’s Infinium methylation probes. However, the complexity of SNPs impact on the methylation level measurements (β values) has not been comprehensively… Expand
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