Impact of Renin-Angiotensin-Aldosterone System Gene Polymorphisms on Left Ventricular Dysfunction in Coronary Artery Disease Patients

@article{Mishra2012ImpactOR,
  title={Impact of Renin-Angiotensin-Aldosterone System Gene Polymorphisms on Left Ventricular Dysfunction in Coronary Artery Disease Patients},
  author={Avshesh Mishra and Anshika Srivastava and Tulika Mittal and Naveen Garg and Balraj Mittal},
  journal={Disease markers},
  year={2012},
  volume={32},
  pages={33 - 41}
}
Background: Left ventricular dysfunction (LVD), followed by fall in cardiac output is one of the major complications in some coronary artery disease (CAD) patients. The decreased cardiac output over time leads to activation of the renin-angiotensin-aldosterone system which results in vasoconstriction by influencing salt-water homeostasis. Therefore, the purpose of the present study was to explore the association of single nucleotide polymorphisms (SNPs) in angiotensin I converting enzyme; ACE… 

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References

SHOWING 1-10 OF 47 REFERENCES
AT1 receptor A/C1166 polymorphism contributes to cardiac hypertrophy in subjects with hypertrophic cardiomyopathy.
TLDR
It is concluded that the AT1-R C1166 allele modulates the phenotypic expression of hypertrophy in HCM, independently of plasma renin and the ACE I/D polymorphism.
Associations between human aldosterone synthase (CYP11B2) gene polymorphisms and left ventricular size, mass, and function.
TLDR
Genetic variations in or near the aldosterone synthase (CYP11B2) gene strongly affect left ventricular size and mass in young adults free of clinical heart disease and may also influence the response of the left ventricle to increases in dietary salt.
Lack of association between a polymorphism of the aldosterone synthase gene and left ventricular structure.
TLDR
The data are not in favor of a significant contribution of the C/T exchange at position -344 in the aldosterone synthase transcriptional regulatory region to the variability of serum ald testosterone levels, blood pressure, or cardiac size or function as found in 2 white population-based samples.
Angiotensin I converting enzyme gene polymorphism and coronary heart disease.
TLDR
BecauseACE polymorphism modulates local production of angiotensin II, a powerful coronary vasoconstrictor, it may influence left ventricular mass in general as well as in coexisting disease states such as hypertension and cardiomyopathy, however, further study is needed to clarify the implications of ACE polymorphism in patients withleft ventricular hypertrophy.
Angiotensin-converting enzyme and angiotensin II receptor 1 polymorphisms: association with early coronary disease.
Aldosterone excretion rate and blood pressure in essential hypertension are related to polymorphic differences in the aldosterone synthase gene CYP11B2.
TLDR
Urinary aldosterone excretion rate may be a useful intermediate phenotype linking these genotypes to raised BP, and it is possible that the polymorphisms may be in linkage with other causative mutations.
Genetic polymorphisms and coronary artery disease in the south of France.
TLDR
Genotype distributions of ACE, PAI-1 and Factor XIII polymorphisms were similar in patients and in controls, and a role of ATIR gene polymorphism in myocardial infarction and vasospastic angina is favored.
ACE gene insertion/deletion polymorphism has a mild influence on the acute development of left ventricular dysfunction in patients with ST elevation myocardial infarction treated with primary PCI
TLDR
It is suggested that the I/D polymorphism of ACE is associated with the development of LV dysfunction in the acute phase after STEMI, and for the first time an association of the low ACE activity with the severe LV dysfunction is demonstrated.
...
1
2
3
4
5
...