Impact of Pseudomonas aeruginosa genomic instability on the application of typing methods for chronic cystic fibrosis infections.

@article{Fothergill2010ImpactOP,
  title={Impact of Pseudomonas aeruginosa genomic instability on the application of typing methods for chronic cystic fibrosis infections.},
  author={Joanne L. Fothergill and Judith White and Juliet E Foweraker and Martin John Walshaw and Martin James Ledson and Eshwar Mahenthiralingam and Craig Winstanley},
  journal={Journal of clinical microbiology},
  year={2010},
  volume={48 6},
  pages={2053-9}
}
The Liverpool epidemic strain (LES) of Pseudomonas aeruginosa is widespread among cystic fibrosis (CF) patients in the United Kingdom and has emerged recently in North America. In this study, we report the analysis of 24 "anomalous" CF isolates of P. aeruginosa that produced inconsistent results with regard to either pulsed-field gel electrophoresis (PFGE) or PCR tests for the LES. We used a new typing method, the ArrayTube genotyping system, to determine that of the 24 anomalous isolates… CONTINUE READING

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