Impact of Progesterone on Molecular Mechanisms of Preterm Premature Rupture of Membranes

@article{Lee2021ImpactOP,
  title={Impact of Progesterone on Molecular Mechanisms of Preterm Premature Rupture of Membranes},
  author={Bang Hyun Lee and Errol R. Norwitz and I. S. Hwang and Jae-Yeon Woo and Sung-Ook Hwang and Hee-Joong Lee},
  journal={Reproductive Sciences},
  year={2021},
  volume={28},
  pages={3137 - 3146}
}
The role and mechanisms of progesterone in preterm premature rupture of membranes (PPROM) remains unclear. This study aims to investigate the molecular mechanisms of action of progesterone in pre-labor full-term fetal amniotic membrane cells with and without stimulation by microbial, pro-inflammatory, or thrombogenic agents. Fetal amniotic membranes were collected from 30 women with a normal singleton pregnancy undergoing elective cesarean section at term prior to the onset of labor. The human… 

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