Impact of Progesterone on Molecular Mechanisms of Preterm Premature Rupture of Membranes

  title={Impact of Progesterone on Molecular Mechanisms of Preterm Premature Rupture of Membranes},
  author={Bang Hyun Lee and Errol R. Norwitz and I. S. Hwang and Jae-Yeon Woo and Sung-Ook Hwang and Hee-Joong Lee},
  journal={Reproductive Sciences},
  pages={3137 - 3146}
The role and mechanisms of progesterone in preterm premature rupture of membranes (PPROM) remains unclear. This study aims to investigate the molecular mechanisms of action of progesterone in pre-labor full-term fetal amniotic membrane cells with and without stimulation by microbial, pro-inflammatory, or thrombogenic agents. Fetal amniotic membranes were collected from 30 women with a normal singleton pregnancy undergoing elective cesarean section at term prior to the onset of labor. The human… 


Progesterone Inhibits Basal and TNF-α-Induced Apoptosis in Fetal Membranes: A Novel Mechanism to Explain Progesterone-Mediated Prevention of Preterm Birth
Progesterone inhibits basal and TNF-α-induced apoptosis in term fetal membranes, which may explain in part the mechanism by which progesterone supplementation prevents PPROM and PTB in some high-risk women.
Progesterone Inhibits Apoptosis in Fetal Membranes by Altering Expression of Both Pro- and Antiapoptotic Proteins
The data provide a mechanism by which progesterone supplementation may prevent PPROM and PTB in some women at high risk of pregnancy by suppressing expression of the proapoptotic protein, BID (for both basal and TNFα-induced apoptosis), and upregulatingexpression of the antiap optotic proteins, XIAP and Bcl-2 (under basal conditions only).
Maternal serum and amniotic fluid cytokines in patients with preterm premature rupture of membranes with and without intrauterine infection
  • A. Shobokshi, M. Shaarawy
  • Medicine, Biology
    International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics
  • 2002
Apoptosis in the chorion of fetal membranes in preterm premature rupture of membranes.
It is suggested that apoptosis is accelerated in the chorion of PPROM subjects with chorioamnionitis, which is supportive of the hypothesis that inflammation accelerates cell death and destruction of the Chorion.
NOD1 and NOD2 Regulate Proinflammatory and Prolabor Mediators in Human Fetal Membranes and Myometrium via Nuclear Factor-Kappa B1
  • M. Lappas
  • Biology, Medicine
    Biology of reproduction
  • 2013
NOD1 and NOD2 are increased in laboring fetal membranes and myometrium and with bacterial infection, and may represent therapeutic targets for the treatment and/or management of preterm birth.
Synergy and Interactions Among Biological Pathways Leading to Preterm Premature Rupture of Membranes
This work hypothesizes that pathways to PPROM overlap and act synergistically to weaken membranes, and focuses on membrane composition and strength, pathways linking risk factors to membrane weakening, and future research directions to reduce the global burden of PPRom.
Placental TLR/NLR expression signatures are altered with gestational age and inflammation
  • Navin Kumar, P. Nandula, H. Menden, J. Jarzembowski, V. Sampath
  • Biology, Medicine
    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
  • 2017
Increase in NFKBIA seen in PPROM and CA might represent a counter regulatory mechanism to decrease inflammation in these conditions and speculate this upregulation may be involved in initiating labor and delivery at term.