Impact of Premature Atrial Contractions in Atrial Fibrillation

  title={Impact of Premature Atrial Contractions in Atrial Fibrillation},
  author={Thomas J. Jensen and Jens Haarbo and Steen Pehrson and B. Thomsen},
  journal={Pacing and Clinical Electrophysiology},
In spite of the increasing knowledge about paroxysmal atrial fibrillation (PAF), details on mode of initiation in unselected patients are scarce. This paper focuses on trigger mechanisms of spontaneous onset of AF in consecutive patients with PAF. One hundred eight consecutive patients with two or more ECG documented AF episodes within the previous year had a 24‐hours Holter recording performed. All AF episodes (n = 157) were reviewed and, within the last 10 beats prior to AF initiation. PP… 
Paroxysmal atrial fibrillation is uncommon in outpatients with chronic heart failure
Evaluating the prevalence of paroxysmal atrial fibrillation in patients with heart failure (HF) due to systolic dysfunction found the presence of AR did not predict development of new-onset AF and the clinical and prognostic importance of AR deserves further investigation.
Paroxysmal atrial fibrillation initiated by late coupled atrial extrasystoles.
Longitudinal dissociation in the re-entrant pathway of the extrasystoles is suggested as a possible mechanism for such initiation of paroxysmal atrial fibrillation.
Mechanism Underlying Initiation of Paroxysmal Atrial Flutter/Atrial Fibrillation by Ectopic Foci: A Simulation Study
It is suggested that a mechanism of dynamically induced repolarization dispersion, especially discordant alternans, underlies the induction of atrial flutter/atrial fibrillation by atrial ectopic foci.
Outpatient cardiac telemetry detects a high rate of atrial fibrillation in cryptogenic stroke
Premature Atrial Contractions in the General Population: Frequency and Risk Factors
PAC frequency is independently associated with age, height, history of cardiovascular disease, natriuretic peptide levels, physical activity, and high-density lipoprotein cholesterol and the underlying mechanisms of these relationships need to be addressed in future studies.


Initiating mechanisms of paroxysmal atrial fibrillation.
Assessing HR and heart rate variability (HRV) changes before the onset of AF using 24-h Holter electrocardiographic analysis in patients without antiarrhythmic medication concluded that Spectral HRV parameters are not useful to foresee AF onset.
The role of atrial ectopics in initiating paroxysmal atrial fibrillation.
Paroxysmal atrial fibrillation is preceded by ectopics of a fixed coupling interval in a significant proportion of patients, and Holter techniques may provide a useful screening tool with which to identify patients suitable for fuller electrophysiological assessment.
Spontaneous initiation of atrial fibrillation by ectopic beats originating in the pulmonary veins.
The pulmonary veins are an important source of ectopic beats, initiating frequent paroxysms of atrial fibrillation and these foci respond to treatment with radio-frequency ablation.
Atrial fibrillation begets atrial fibrillation. A study in awake chronically instrumented goats.
Artificial maintenance of AF leads to a marked shortening of AERP, a reversion of its physiological rate adaptation, and an increase in rate, inducibility and stability of AF.
Incidence and modes of onset of early reinitiation of atrial fibrillation after successful internal cardioversion, and its prevention by intravenous sotalol
Intravenous sotalol infusion decreased the numbers of atrial premature beats and prolonged their coupling interval, and prevented ERAF after repeated defibrillation in 83% of patients with ERAF and was effective in preventing ERAF in most cases.