Impact of Pathologists and Evaluation Methods on Performance Assessment of the Kidney Injury Biomarker, Kim-1.

@article{Rouse2015ImpactOP,
  title={Impact of Pathologists and Evaluation Methods on Performance Assessment of the Kidney Injury Biomarker, Kim-1.},
  author={Rodney Rouse and Min Min and Sabine Francke and Steven R. Mog and Jun Zhang and Katherine I Shea and S R Jamieson Stewart and Thomas Colatsky},
  journal={Toxicologic pathology},
  year={2015},
  volume={43 5},
  pages={
          662-74
        }
}
Attempts to characterize and formally qualify biomarkers for regulatory purposes have raised questions about how histological and histopathological methods impact the evaluation of biomarker performance. A group of pathologists was asked to analyze digitized images prepared from rodent kidney injury experiments in studies designed to investigate sources of variability in histopathology evaluations. Study A maximized variability by using samples from diverse studies and providing minimal… CONTINUE READING
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