Impact of Opiate–HIV-1 Interactions on Neurotoxic Signaling

  title={Impact of Opiate–HIV-1 Interactions on Neurotoxic Signaling},
  author={Kurt F Hauser and Nazira El-Hage and Shreya K Buch and Avindra Nath and William R Tyor and Annadora J Bruce-Keller and Pamela E Knapp},
  journal={Journal of Neuroimmune Pharmacology},
Opiate drug abuse exacerbates the pathogenesis of human immunodeficiency virus-1 (HIV-1) in the central nervous system through direct actions on glia and neurons. Opiate abuse causes widespread disruption of astroglial and microglial function, and significant increases in astroglial-derived proinflammatory cytokines and chemokines, which likely contributes to neuronal dysfunction, death, and HIV encephalitis. Neurons are also directly affected by opiate–HIV-1 interactions. HIV-1 and the viral… CONTINUE READING